Brain Fog & Mood

Can creatine ease menopausal brain fog? A new RCT shows promise, but Adelaide practitioner Rohan Smith explains why testing comes first.

Brain fog and neuroinflammation: what the evidence actually shows By Rohan Smith · Functional & Nutritional Medicine, Adelaide · Published May 25, 2026 Quick Answer Brain fog is not a diagnosis. It is a cluster of symptoms that many different problems can produce: slowed thinking, poor focus, weak short-term memory, mental fatigue. The trending explanation…

Author: Rohan Smith | Functional Medicine Practitioner | Adelaide, SA Quick Answer Chronic tiredness, brain fog, and low mood may be linked to impaired mitochondrial function. Mitochondria produce adenosine triphosphate (ATP), the cell’s primary energy currency, and the brain consumes approximately 20% of total body energy output. When mitochondrial ATP production is disrupted, neurotransmitter signalling,…

Author: Rohan Smith | Functional Medicine Practitioner | Adelaide, SA Quick Answer Copper-zinc imbalance may contribute to the “wired but tired” pattern experienced by some individuals with anxiety. Copper serves as a cofactor for dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine. When copper is elevated relative to zinc, this shift in catecholamine…

Author: Rohan Smith | Functional Medicine Practitioner | Adelaide, SA Quick Answer Mouth breathing may activate the sympathetic nervous system (SNS), potentially contributing to heightened anxiety, disrupted sleep, and reduced oxygen delivery to tissues. Nasal breathing, by contrast, can promote parasympathetic balance and increase nitric oxide production, which is associated with improved blood pressure regulation,…

Author: Rohan Smith | Functional Medicine Practitioner | Adelaide, SA Quick Answer Straw breathing is a vagus nerve activation technique that may help reduce anxiety by extending exhalation, which stimulates the parasympathetic nervous system. Inhaling through the nose and exhaling slowly through a narrow straw can shift autonomic nervous system balance away from sympathetic “fight…

Author: Rohan Smith | Functional Medicine Practitioner | Adelaide, SA Quick Answer Chronic low-grade inflammation may be a significant biological driver of depression and anxiety. Pro-inflammatory cytokines, including interleukin-6 (IL-6), C-reactive protein (CRP), and tumour necrosis factor-alpha (TNF-alpha), have been consistently associated with depressive symptoms and may impair neurotransmitter synthesis, HPA axis regulation, and treatment…

Author: Rohan Smith | Functional Medicine Practitioner | Adelaide, SA Quick Answer Treatment-resistant depression, which may affect up to one-third of people on antidepressants according to the STAR*D trial, can be associated with unaddressed nutritional deficiencies, impaired methylation via the MTHFR pathway, and chronic neuroinflammation. Because SSRIs and SNRIs recycle existing neurotransmitters rather than producing…

Author: Rohan Smith | Functional Medicine Practitioner | Adelaide, SA Quick Answer Cyclical fluctuations in oestrogen and progesterone across the menstrual cycle can significantly worsen ADHD symptoms in the premenstrual (late luteal) phase. Oestrogen supports dopamine signalling in the prefrontal cortex, so when oestrogen declines after ovulation, dopamine activity may drop in parallel, intensifying brain…