Methylation Panel – Doctors Data
$497.00
Comprehensive blood panel by Doctor’s Data measuring key methylation cycle metabolites — including homocysteine, SAM, SAH, methionine, cysteine, and glutathione. Reveals how efficiently your body runs its methylation pathways, which govern detoxification, neurotransmitter production, DNA repair, and energy metabolism.
Description
What Is the Methylation Panel?
The Methylation Panel by Doctor’s Data is a blood test that directly measures the key metabolites involved in the methylation cycle — one of the most fundamental biochemical processes in the human body. Methylation governs DNA repair, neurotransmitter synthesis, detoxification, histamine clearance, hormone metabolism, and cellular energy production.
Unlike genetic tests (such as MTHFR), which only tell you what could happen based on your genes, the Methylation Panel measures what is actually happening in your biochemistry right now. This makes it an essential complement to genetic testing and a critical tool for patients with complex chronic conditions.
What Does It Measure?
S-Adenosylmethionine (SAM)
The body’s primary methyl donor — required for over 200 enzymatic reactions. Low SAM indicates impaired methylation capacity and is associated with depression, fatigue, and poor detoxification.
S-Adenosylhomocysteine (SAH)
The byproduct of methylation reactions. Elevated SAH inhibits methyltransferase enzymes and signals a bottleneck in the methylation cycle.
SAM/SAH Ratio
The single most important marker on this panel. A low ratio indicates functional methylation impairment regardless of individual SAM or SAH levels.
Homocysteine
A sulphur-containing amino acid that accumulates when methylation and transsulphuration pathways are impaired. Elevated homocysteine is an independent risk factor for cardiovascular disease, neurodegeneration, and pregnancy complications.
Methionine
The essential amino acid that feeds into the methylation cycle. Low methionine can indicate poor dietary intake, malabsorption, or excessive demand on methylation pathways.
Cysteine & Cystathionine
Downstream markers of the transsulphuration pathway — the route that converts homocysteine into glutathione (the body’s master antioxidant). These reveal whether your body is effectively clearing homocysteine and producing adequate glutathione.
Who Should Consider This Test?
This test is particularly valuable for patients experiencing:
• Known MTHFR or methylation gene variants — to see if genetics are actually translating into functional impairment
• Depression, anxiety, or mood instability — especially if resistant to standard treatment
• Chronic fatigue that hasn’t responded to basic nutritional support
• Elevated homocysteine on standard blood work
• Chemical sensitivity, histamine intolerance, or mast cell activation
• Recurrent miscarriage or fertility issues
• Family history of cardiovascular disease, dementia, or neural tube defects
• Patients on long-term medications that deplete B vitamins (metformin, PPIs, oral contraceptives)
Sample Collection
Sample type: Blood draw (venipuncture)
Collection method: Collected at an approved pathology collection centre — Rohan will provide a referral
Fasting required: Overnight fast preferred (12 hours)
Supplements: Discuss with Rohan — B12, folate, and methyl-donor supplements may need to be paused before collection for accurate baseline results
Turnaround Time
Results are typically returned within 4 weeks from the date the laboratory receives your sample. Samples are processed in the USA by Doctor’s Data’s ISO-accredited laboratory.
What Happens After You Order
1. Test kit delivered to you — This will provide guidance on where to book your blood collection.
2. Blood draw — Attend an approved collection centre for a standard blood draw.
3. Lab processing — Your sample is shipped to Doctor’s Data for analysis.
4. Results released to you — If you’re an existing patient, Rohan will go through the results with you at your next appointment. If you have your own practitioner, you’re welcome to order through Elemental Health and share the results with them directly.
Why Choose Elemental Health?
Methylation is one of Rohan’s core clinical specialties. He has spent 13 years interpreting methylation panels alongside genetic data for patients with complex mood, fatigue, and detoxification issues. Every result is reviewed in the context of your full clinical picture — not just flagged ranges. Your consultation will include a clear, prioritised strategy covering targeted supplementation, dietary methylation support, and any further testing needed.
