MTHFR & Methylation

MTHFR is one enzyme in the folate cycle. MTHFD1, MTR and MTRR shape it too, which is why homocysteine and active B12 guide treatment, not a gene result.

MTHFR gene variants can slow methylation, the process behind serotonin and dopamine. How the mutation may affect mood, and which tests actually show it.

Poor methylation may sit behind fatigue and brain fog that bloods call normal. How MTHFR variants limit B12 and folate use, and which tests reveal it.

Glutathione may protect the thyroid. Making thyroid hormone generates hydrogen peroxide, and glutathione neutralises it before it damages thyroid cells.

MTHFR testing in Adelaide looks at the C677T and A1298C gene variants that slow folate activation. What carrying a variant means, and what it does not mean.

Methylation panel testing in Adelaide measures SAMe, SAH and homocysteine to show how well your methylation cycle is running, not just which genes you carry.

Author: Rohan Smith | Functional Medicine Practitioner | Adelaide, SA Quick Answer MTHFR (methylenetetrahydrofolate reductase) is a key enzyme in one-carbon metabolism that converts dietary folate into its active form, 5-methyltetrahydrofolate (5-MTHF). While “activated” B vitamins such as methylfolate and methylcobalamin may benefit some individuals with MTHFR C677T or A1298C variants, they are not universally…