Organic Acid Test (OAT) – Mosaic Diagnostics
Price range: $436.50 through $616.50
Comprehensive urine metabolic test by Mosaic Diagnostics measuring 76 organic acid markers across energy production, neurotransmitter metabolism, nutrient cofactors, detoxification, and microbial overgrowth (yeast and bacteria). One of the most clinically powerful functional tests available — providing a metabolic snapshot that connects gut, brain, mitochondria, and nutrient status in a single panel.
What is the Organic Acid Test?
The Organic Acid Test (OAT) by Mosaic Diagnostics (formerly Great Plains Laboratory) is a comprehensive urine test that measures 76 organic acid metabolites — small molecules produced as byproducts of cellular metabolism. These markers provide a functional snapshot of how your body is actually performing at a biochemical level, revealing imbalances in energy production, neurotransmitter turnover, nutrient cofactors, detoxification pathways and microbial overgrowth.
The OAT is one of the most clinically powerful functional tests available because it connects multiple body systems in a single panel — linking gut health, mitochondrial function, brain chemistry and nutritional status in ways that standard blood work cannot.
Is this test for you?
The OAT is for complex cases where multiple body systems appear to be involved and standard testing has stalled:
- Chronic fatigue, low energy or post-viral exhaustion
- Brain fog, poor concentration or memory issues
- Mood disorders — depression, anxiety, irritability — especially treatment-resistant
- Bloating, sugar cravings or suspected yeast/Candida overgrowth
- Behavioural or developmental concerns in children (ADHD, autism spectrum)
- Fibromyalgia or chronic pain syndromes
- Nutrient deficiency symptoms despite supplementation
- Complex chronic illness where multiple body systems appear affected
- Anyone wanting the single most comprehensive metabolic overview available
What it measures
Six interconnected metabolic categories — the OAT's strength is that it shows the relationships between them, not just isolated markers.
Krebs Cycle / Mitochondria
Citric, succinic, fumaric, malic and hydroxymethylglutaric acid. Reveals how efficiently mitochondria are producing ATP. Commonly abnormal in chronic fatigue, fibromyalgia and post-viral syndromes.
Neurotransmitter Metabolites
Homovanillic acid (dopamine), vanilmandelic acid (noradrenaline/adrenaline), 5-hydroxyindoleacetic acid (serotonin), quinolinic acid (neuroinflammation). Critical for mood disorders, anxiety, ADHD and cognitive complaints.
Yeast & Fungal Markers
Arabinose, tartaric acid, citramalic acid and others. Elevated yeast metabolites are among the most common OAT findings — associated with brain fog, sugar cravings and bloating. Often reveals Candida that stool testing misses.
Bacterial Markers (Clostridia)
HPHPA, 4-cresol, 3-indoleacetic acid. Indicate overgrowth of pathogenic bacterial species — particularly Clostridia, which produce neurotoxic metabolites linked to mood, behaviour and neurological symptoms.
Oxalate Markers
Glyceric, glycolic and oxalic acid. Elevated oxalates indicate oxalate overproduction or poor clearance — associated with kidney stones, joint pain and chronic inflammation.
Nutritional Cofactors
Methylmalonic acid (B12), formiminoglutamic acid (folate), xanthurenate/kynurenate (B6), pyroglutamic acid (glutathione), ascorbic acid (vitamin C). Functional markers reveal deficiencies even when serum levels look normal.
Sample collection
Turnaround time
From the date the laboratory receives your sample.
Samples are processed in the United States by Mosaic Diagnostics — the originating laboratory for organic acid testing in functional medicine.
How it works
Kit dispatched
Your OAT collection kit is posted directly to your door with full instructions.
Collect at home
Follow the first morning urine protocol and freeze the sample.
Ship to lab
Ship the frozen sample to the lab using the provided materials.
Results released
Your report is emailed to you the moment the lab releases it. What happens next depends on your tier —
- Test only: the report is yours to use as you see fit — no consultation included. You can book a separate consultation with Rohan later if you change your mind.
- Test + 60-min Telehealth Consult: once your results land, Rohan will email you a booking link to schedule your Zoom.
- Existing patients of the clinic: results are typically discussed at your next regular appointment as usual.
Why this test, why now?
For patients whose symptoms span multiple body systems — fatigue plus mood plus gut plus cognitive complaints — the OAT is unmatched. It is the single test that shows how gut microbial overgrowth feeds into neurotransmitter dysfunction, how mitochondrial output is being throttled, where the nutrient bottlenecks are.
For complex chronic cases the alternative is often running 3–4 separate tests to see what the OAT shows in one panel.
Why Elemental Health and Nutrition?
The OAT is one of Rohan's most-used and most-valued functional tests — he considers it the single best metabolic overview available for complex chronic patients. With Test + 60-min Telehealth Consult, your appointment delivers a clear, prioritised treatment strategy that addresses the highest-impact findings first, covering antimicrobial protocols, mitochondrial support, targeted supplementation, dietary adjustments and any further testing needed.
